ProductOverview
ThemammalianKrüppel-liketranscriptionfactor4(Klf4)isanevolutionarilyconservedzincfinger-containingtranscriptionfactorwithdiverseregulatoryfunctionsincellgrowth,proliferation,differentiationandembryogenesis.ItalsoplaysasignificantroleintheprocessoftumOrigenesis.Klf4isoneofthekeytranscriptionfactorsthathavebeenusedtoreprogrammouseandhumanfibroblaststoinducedpluripotentstem(iPS)cells.
ProductSpecifications
Size
100μl
Concentration
0.25mg/ml
Clone
56CT5.1.6
Isotype
MouseIgG1,κ
Immunogen
HumanKlf4recombinantprotein
Reactivity
Mouse,Human
Preparation
Thisantibodywaspurifiedbyaffinitychromatography.
Formulation
Phosphate-bufferedsolution,pH7.2,0.1%sodiumazide,and0.2%BSA
StorageandStABIlity
Storeat4˚Cprotectedfromlight.Donotfreeze.Stablefor6monthsfromdateofreceiptwhenstoredasdirected.
QualityControl
Testedbyimmunocytochemistrytoensureproductquality.
RecommendedUsage
Thesuggesteduseofthisantibodyisa1:100dilutionforimmunocytochemistry.Foranapplicationspecificprotocol,pleasereferenceProtocol:Immunocytochemistryonlineatwww.Stemgent.com/support/protocols.
SpecificationSheets
- 09-0021SpecificationsSheet
SafetyDataSheets
- 09-0021SafetyDataSheet
Protocols
- Protocol:Immunocytochemistry
References
- Chen,X.,Whitney,E.M.,Gao,S.Y.,andYang,V.W.(2003)TranscriptionalprofilingofKrüppel-likefactor4revealsafunctionincellcycleregulationandepithelialdifferentiation.JMolBiol.326:665-677.
- Ghaleb,A.M.,Nandan,M.O.,Chanchevalap,S.,Dalton,W.B.,Hisamuddin,I.M.,andYang,V.W.(2005)Krüppel-likefactors4and5:theyinandyangregulatorsofcellularproliferation.CellRes.15:92-96.
- Takahashi,K.,andYamanaka,S.(2006).Inductionofpluripotentstemcellsfrommouseembryonicandadultfibroblastculturesbydefinedfactors.Cell126,663-676.
- Takahashi,K.,TanabeK.,Ohnuki,M.,Narita,M.,IchisakaT.,TomodaK.andYamanaka,S.(2007)Inductionofpluripotentstemcellsfromadulthumanfibroblastsbydefinedfactors.Cell131:861-872.
- Park,I.H.,Arora,N.,Huo,H.,Maherali,N.,Ahfeldt,T.,Shimamura,A.,Lensch,M.W.,Cowan,C.,Hochedlinger,K.,andDaley,G.Q.(2008)Disease-specificinducedpluripotentstemcells.Cell134:877-886.
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